INM – Leibniz-Institut für Neue Materialien gGmbH

INM is focused on the research and development of materials – for today, tomorrow and the future. Chemists, physicists, biologists, materials and engineering scientists shape the work at INM. From molecule to pilot production, they follow the recurring questions: Which material properties are new, how can they be investigated and how can they be used in the future?

INM – Leibniz Institute for New Materials, situated in Saarbrücken/Germany, is an internationally leading center for materials research. It is a scientific partner to national and international institutes and a provider of research and development for companies throughout the world. INM is an institute of the Scientific Association Gottfried Wilhelm Leibniz and employs around 180 collaborators. Its main research fields are Nanocomposite Technology, Interface Materials, and Biointerfaces.

The program division Nano Cell Interactions investigates the interactions between human cells and engineered nanoparticles. More specifically, our work includes the testing of nanoparticles for their pharmaceutical and biomedical applicability, for example as contrast agents, always taking into account their toxicological potential. The overarching aim is to explore and describe the mechanisms involved in the cellular responses to nanoparticle exposure and to analyze their role in nanoparticle uptake and subcellular distribution.

Principal fields of interest are:
•    Production, modification, functionalization and characterization of nanoparticles
•    In vitro studies on relevant cell systems using cell-based assays (cytotoxicity, cytokine secretion, etc.)
•    Determination of endotoxins in nanoparticle dispersions
•    Molecular analyses of particle-induced effects (e.g. RT-PCR)
•    Microscopy imaging: STED microscopy, two-photon microscopy, live cell imaging, dark-field microscopy, and electron microscopy