PharmBioTec GmbH

PharmBioTec GmbH is a Research Organization offering high quality services in Biotechnological/Biopharmaceutical R&D. In 2010 three professors of Saarland University (Prof. Hartmann, Prof. Müller and Prof. Lehr) have combined their extensive knowledge experience in design, synthesis, biological evaluation, formulation and analysis of new drugs to form a young and flexible organization that facilitates free flowing innovation transfer between research and industry. PharmBioTec is a 100% subsidiary of Saarland University and operates in close cooperation with the pharmacy as well as the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS).

In Drug Delivery, there is large expertise in studying drug transport across biological barriers using advanced in-vitro models, in particular of the intestinal mucosa, skin and lungs. Furthermore, appropriate carriers are developed capable of crossing these epithelial barriers and delivering an active molecule to the target.

Biotechnology/Analytics focusses on the development and validation of analytical methods for macromolecular substances in a GMP enviroment, e.g. proteins and peptides as well as small molecules. An additional area is formulation development, in case of proteins often freeze-drying cycles were developed and optimized.

A main topic is the analysis and characterization of therapeutic proteins. The guideline ICHQ6B demands an in-depth analysis of biopharmaceuticals in respect to physicochemical properties (composition, physical properties, primary structure), purity and quantity. For this purpose the following techniques are available at PharmBioTec: UV, IR, SDS-PAGE, CE-SDS, in-Gel digestion and identification of gel bands via MS/MS, IEF, RP-, SE-, IX-HPLC, CE, CE-MS, Peptide Mapping, HCP Assays, ELISA, WB, 2D-DIGE, LC-MS, ultra high-resolution mass spectrometry. Additional techniques are: determination of water content in lyophilisates with Karl-Fischer with oven-technology, double oven differential scanning calorimetry, polarimetry, determination of refraction index, osmolality and melting point. These techniques are also available for small molecules and other applications.